Genetics of aggression

The field of psychology has been greatly influenced by the study of genetics. Decades of research has demonstrated that both genetic and environmental factors play a role in a variety of behaviors in humans and animals (e.g. Grigorenko & Sternberg, 2003). The genetic basis of aggression, however, remains poorly understood. Aggression is a multi-dimensional concept, but it can be generally defined as behavior that inflicts pain or harm on another. Genetic-developmental theory states that individual differences in a continuous phenotype result from the action of a large number of genes, each exerting an effect that works with environmental factors to produce the trait.[1] Because this type of trait is influenced by multiple factors, it is more complex and difficult to study than a simple Mendelian trait (one gene for one phenotype). Past thought on genetic factors influencing aggression tended to seek answers from chromosomal abnormalities.[citation needed] Specifically, four decades ago, the XYY genotype was (erroneously) believed by many to be correlated with aggression. In 1965 and 1966, researchers at the MRC Clinical & Population Cytogenetics Research Unit led by Dr. Court Brown at Western General Hospital in Edinburgh reported finding a much higher than expected nine XYY men (2.9%) averaging almost 6 ft. tall in a survey of 314 patients at the State Hospital for Scotland; seven of the nine XYY patients were mentally retarded.[2] In their initial reports published before examining the XYY patients, the researchers suggested they might have been hospitalized because of aggressive behavior. When the XYY patients were examined, the researchers found their assumptions of aggressive behavior were incorrect. Unfortunately, many science and medicine textbooks quickly and uncritically incorporated the initial, incorrect assumptions about XYY and aggression—including psychology textbooks on aggression.[3] The XYY genotype first gained wide notoriety in 1968 when it was raised as a part of a defense in two murder trials in Australia and France. In the United States, five attempts to use the XYY genotype as a defense were unsuccessful—in only one case in 1969 was it allowed to go to a jury—which rejected it.[4] Results from several decades of long-term follow-up of scores of unselected XYY males identified in 8 international newborn chromosome screening studies in the 1960s and 1970s have replaced pioneering but biased studies from the 1960s (that used only institutionalized XYY men), as the basis for current understanding of the XYY genotype and established that XYY males are characterized by increased height but are not characterized by aggressive behavior.[5][6] Today the link between genetics and aggression has turned to a different aspect of genetics than chromosomal abnormalities but it is important to understand where the research started to understand the direction it is moving towards today. Aggression, as well as other behavioral traits, is studied genetically based on its heritability through generations. Heritability models of aggression are mainly based on animals due to the ethical concern in using humans for genetic study. Animals are first selectively bred and then placed in a variety of environmental conditions, allowing researchers to examine the differences of selection in the aggression of animals.[citation needed] Research methods As with other topics in behavioral genetics, aggression is studied in three main experimental ways to help identify what role genetics plays in the behavior: Heritability studies – studies focused to determine whether a trait, such as aggression, is heritable and how it is inherited from parent to offspring. These studies make use of genetic linkage maps to identify genes associated with certain behaviors such as aggression. Mechanism experiments – studies to determine the biological mechanisms that lead certain genes to influence types of behavior like aggression. Genetic behavior correlation studies – studies that use scientific data and attempt to correlate it with actual human behavior. Examples include twin studies and adoption studies. These three main experimental types are used in animal studies, studies testing heritability and molecular genetics, and gene interaction/environment studies. Recently, important links between aggression and genetics have been studied and the results are allowing scientists to better understand the connections.[7] Selective breeding The heritability of aggression has been observed in many animal strains after noting that some strains of birds, dogs, fish, and mice seem to be more aggressive than other strains. Selective breeding has demonstrated that it is possible to select for genes that lead to more aggressive behavior in animals.[7] Selective breeding examples also allow researchers to understand the importance of developmental timing for genetic influences on aggressive behavior. A study done in 1983 (Cairns) produced both highly aggressive male and female strains of mice dependent on certain developmental periods to have this more aggressive behavior expressed. These mice were not observed to be more aggressive during the early and later stages of their lives but during certain periods of time (in their middle-age period) were more violent and aggressive in their attacks on other mice.[8] Selective breeding is a quick way to select for specific traits with the effects of selection being seen within a few generations of breeding. These characteristics make selective breeding an important tool in the study of genetics and aggressive behavior. [edit]Mouse studies Mice are often used as a model for human genetic behavior since mice and humans have homologous genes coding for homologous proteins that are used for similar functions at some biological levels.[9] Mice aggression studies have led to some interesting insight in human aggression. Using reverse genetics, the DNA of genes for the receptors of many neurotransmitters have been cloned and sequenced, and the role of neurotransmitters in rodent aggression has been investigated using pharmacological manipulations. Serotonin has been identified in the offensive attack by male mice against intruder male mice. Mutants were made by manipulating a receptor for serotonin by deleting a gene for the serotonin receptor. While exhibiting normal behavior in everyday activities such as eating and exploration, these mutant male mice with the knockout alleles attacked intruders with twice the intensity of normal male mice. In offense aggression in mice, males with the same or similar genotypes were more likely to fight than males that encountered males of other genotypes. Another interesting finding in mice dealt with mice reared alone. These mice showed a strong tendency to attack other male mice upon their first exposure to the other animals. The mice reared alone were not taught to be more aggressive; they simply exhibited the behavior. This implicates the natural tendency related to biological aggression in mice because the mice reared alone lacked a parent to show them when to be aggressive